Introduction :The only way of gangrene wounds in diabetes is amputatum. Various surgical procedures make patients fear. Health education helps patients to improve and control emotions.This study aims to determine the effect of health education about amputatum on the level of anxiety pre-operating patientsamputatum gangrene wounds in RSUD Nganjuk. Methods:The design of this study was Pre Experiment with One Group Pre-Post Design Test. The population of this study was 14 patients of pre op amputatum gangreneconducted on 14-17 December 2018 in RSUD Nganjuk and the sample in this study was 14 patientswith total sampling technique. The independent variables in this study washealth education about amputatumand the dependent variable was the level of anxiety.Data collection using SAP and Z-SASquestionnaire. Statistical test using Wilcoxon Signed Range Test with α = 0.05 in SPSS 20. Results:The results of the study of 14patients, the level of anxiety of patients with preoperative amputatum gangrenous injuries before being given health education most of the respondents were 9 respondents (64.3%) included in the category of moderate anxiety and after being given health education in the majority of respondents as many as 9 respondents (64.3%) included in the category of mild anxiety.Wilcoxon test results obtained ρ value = 0.014 with α = 0.05 so that Ha was received, there was an effect of health education about amputatum on the level of anxiety pre-operating patientsamputatum gangrene wounds in RSUD Nganjuk. Conclusion:one way to deal with preoperative amputatum anxiety was by communication.